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Non disease specific models
|
Mechanistic models
|
|
Paw oedema models on rats
|
LPS-induced
|
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Carrageenan-induced
|
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Histamine-induced
|
|
Elastase-induced
|
| Uric acid induced |
| PAR2 agonist (SLIGRL-NH2)-induced |
| |
|
|
Paw oedema models on guinea pig
|
Ovalbumin-induced on ovalbumin sensitized animals
|
| |
|
|
Plasma extarvasation models
|
Capsaicin-induced tracheal and bronchial
|
|
Antigen challenge-induced tracheal and bronchial
|
| |
|
|
Air-pouch models
|
LPS-induced inflammation
|
|
Zymosan-induced inflammation
|
|
Phorbol-12 myristate-13 acetate (PMA)-induced inflammation
|
|
Eotaxin-induced inflammation
|
|
Uric acid-induced inflammation
|
| |
|
|
Organ bath technics
|
Spontaneous trachel tone to test airway smooth muscle relaxing effect
|
|
Constrictor mediator precontracted (contracture) tracheal preparation to test airway smooth muscle relaxing effect
|
| Antagonisation of constrictor mediator-induced constriction to test airway smooth muscle relaxing effect
|
| Electricaly field stimulated tracheal/bronchial preparation
|
| - Cholinergic contraction
|
| - NANC contraction
|
| - NANC relaxation
|
| Intracell Ca pool refill mechnism examination on isolated tracheal preparations changing Ca2+ containing and Ca2+ free medium
|
| “Skinned” tracheal preparation to test intracellular Ca mechanisms
|
| Ascaris suum antigen-induced tracheal constriction in sheep |
| |
|
Lung function measuring
|
Konzett Rössler technics |
| Airway resistance and compliance measuring by pletismograph technics |
| Airway and tissue resistanec and compliance measuring by impedancy |
|
|
